Endocrine Abstracts

Carcinoid tumors (CT) seldom develop in the head and neck area. Several authors doubt the existence of authentic neuroendocrine tumors in the nose. Most of the CT arise in the larynx.Clinical case: A 54 years old woman, who had a right-sided nasal obstruction, rhinorrhea, and sometimes purulent discharge in 2016. In 2002 she had hyperthyroidism by Graves disease and treated for two years with remission after that. The examination of the nose revealed a d...

Metabolic dysfunction in skeletal muscle disturbs both the critical vascular network and fundamental muscle fibre architecture. However, the molecular drivers during metabolic stress responsible for transmitting these events remain poorly defined. To reveal these we mapped changes in the spatial proteome occurring as a result of impaired metabolic health. We exposed male and female mice (C57/BL6J) to high fat diets and conducted digital spatial profiling (NanoString GEOMX) on ...

A prevailing concept regarding the mechanism controlling the timing of puberty proposes that GnRH release from the hypothalamus increases at puberty due to a loss of transsynaptic inhibition, accompanied by an increase in neuronal/glial excitatory inputs to GnRH neurons. Without negating the importance of this intercellular communication process, recent evidence suggests that a critical inhibitory/excitatory Yin-Yang mechanism regulating the advent of puberty is epigenetic in ...

The initiation of mammalian puberty requires an increased pulsatile release of gonadotrophin hormone releasing hormone (GnRH) from the hypothalamus. This increase is brought about by changes in transsynaptic and glial–neuronal communication. Coordination of this regulatory neuronal–glial network likely requires the participation of a multiplicity of genes hierarchically arranged within discrete, but interactive, networks. The identity and structural features of at le...

Nissen’s meta-analysis concluded that the use of Rosiglitazone (RSG) was associated with a significant increase in the risk of myocardial infarction. However, none of the analyzed studies took into account the cardiovascular events as primary outcomes, neither were controlled by cardiovascular risk factors.Objectives: 1. To know if there is an association between RSG myocardial infarction OR and the magnitude of the difference in baseline serum lipi...

Introduction: Craniopharyngiomas are intracranial tumors that develop from Rathke’s pouch rests of epithelium. They have a bimodal age distribution, with peak incidence at childhood and in the adult/elderly, although in our series we have more patients in a middle peak. Usually they are benign but responsible for significant morbidity, particularly when located near critical structures such as optic chiasm, pituitary gland and hypothalamus, and thus might cause visual, ne...

Background: Graves’ Disease (GD) is one of the most common organ specific autoimmune disorders, being characterized by an abnormal production of stimulating autoantibodies to the thyrotropin receptor (TSHR). Some studies demonstrated that genetic polymorphisms in certain cytokines, namely interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), are associated with a greater susceptibility of developing GD. Our aim was to evaluate ...

Introduction: Hypothyroidism caused by autoimmune thyroiditis (AIT) is a disease that can originate physical, psychological and behavioral symptoms. Quality of life (QoL) and psychopathologial symptoms in thyroid diseases and its relation with thyroid function remains unclear. In hypothyroidism there is a discussion about the normal range of TSH and Free T4 values and in which way its fluctuation influences the patient in its daily activities.Objective: ...

Objective: Recent reports have suggested that air pollution may impact thyroid function, although the evidence is still scarce and inconclusive. In this study we evaluated the association of exposure to air pollutants to thyroid function parameters in a nationwide sample representative of the adult population of Spain.Methods: The [email protected] study is a national, cross-sectional, population-based survey which was conducted in 2008-2010 using a random clust...

Introduction: Medullary thyroid cancer is a rare neoplasm, accounting for approximately 4% of all cases of thyroid cancer. Exceptionally, it can be associated with the hormonal production of ACTH or CRH, causing ectopic Cushing’s syndrome.Clinical Case: We present the case of a 43-year-old man who, as a history of interest, presented a T6-T8 vertebral body fracture 2 years ago and a right hip fracture 1 year ago. Bone densitometry is compatible with...